Assuntos
Neoplasias Intestinais , Tumores Neuroendócrinos , Feminino , Humanos , Intestino Delgado , Mesentério , Pessoa de Meia-IdadeAssuntos
Humanos , Feminino , Pessoa de Meia-Idade , Tumores Neuroendócrinos , Neoplasias Intestinais , Intestino Delgado , MesentérioRESUMO
BACKGROUND: Liver transplantation is the usual treatment for hepatocellular carcinoma. AIM: To analyze the MELD score, waiting time and three month and one year survival for liver transplantation in cirrhotic patients affected by hepatocellular carcinoma or not. METHODS: This was a retrospective, observational and analytical study of 93 patients submitted to liver transplantation. RESULTS: There were 28 hepatocellular carcinoma and 65 non-hepatocellular carcinoma patients with no differences related to age and sex distribution. The main causes of cirrhosis on hepatocellular carcinoma were hepatitis C virus (57.1%) and hepatitis B virus (28.5%), more frequent than non-hepatocellular carcinoma patients, which presented 27.7% and 4.6% respectively. The physiological and exception MELD score on hepatocellular carcinoma were 11.9 and 22.3 points. On non-hepatocellular carcinoma, it was 19.4 points, higher than the physiological MELD and lower than the exception MELD on hepatocellular carcinoma. The waiting time for transplantation was 96.2 days for neoplasia, shorter than the waiting time for non-neoplasia patients, which was 165.6 days. Three month and one year survival were 85.7% and 78.6% for neoplasia patients, similar to non-neoplasia, which were 77% and 75.4%. CONCLUSION: Hepatocellular carcinoma patients presented lower physiological MELD score, higher exception MELD score and shorter waiting time for transplantation when compared to non-hepatocellular carcinoma patients. Three month and one year survival were the same between the groups.
Assuntos
Carcinoma Hepatocelular/complicações , Carcinoma Hepatocelular/cirurgia , Cirrose Hepática/complicações , Neoplasias Hepáticas/complicações , Neoplasias Hepáticas/cirurgia , Transplante de Fígado , Adulto , Idoso , Carcinoma Hepatocelular/mortalidade , Feminino , Humanos , Neoplasias Hepáticas/mortalidade , Masculino , Pessoa de Meia-Idade , Modelos Teóricos , Estudos Retrospectivos , Taxa de Sobrevida , Fatores de Tempo , Listas de EsperaRESUMO
Background: Liver transplantation is the usual treatment for hepatocellular carcinoma. Aim : To analyze the MELD score, waiting time and three month and one year survival for liver transplantation in cirrhotic patients affected by hepatocellular carcinoma or not. Methods: This was a retrospective, observational and analytical study of 93 patients submitted to liver transplantation. Results: There were 28 hepatocellular carcinoma and 65 non-hepatocellular carcinoma patients with no differences related to age and sex distribution. The main causes of cirrhosis on hepatocellular carcinoma were hepatitis C virus (57.1%) and hepatitis B virus (28.5%), more frequent than non-hepatocellular carcinoma patients, which presented 27.7% and 4.6% respectively. The physiological and exception MELD score on hepatocellular carcinoma were 11.9 and 22.3 points. On non-hepatocellular carcinoma, it was 19.4 points, higher than the physiological MELD and lower than the exception MELD on hepatocellular carcinoma. The waiting time for transplantation was 96.2 days for neoplasia, shorter than the waiting time for non-neoplasia patients, which was 165.6 days. Three month and one year survival were 85.7% and 78.6% for neoplasia patients, similar to non-neoplasia, which were 77% and 75.4%. Conclusion : Hepatocellular carcinoma patients presented lower physiological MELD score, higher exception MELD score and shorter waiting time for transplantation when compared to non-hepatocellular carcinoma patients. Three month and one year survival were the same between the groups.
Racional : O tratamento habitual do carcinoma hepatocelular é o transplante hepático. Objetivo : Analisar o MELD, o tempo em lista de espera e a sobrevida em três meses e em um ano de pacientes submetidos ao transplante hepático cadavérico e divididos em dois grupos: portadores e não portadores de carcinoma hepatocelular. Método : Estudo analítico, observacional e retrospectivo de 93 pacientes transplantados. Resultados : Os grupos foram similares em relação ao sexo e à idade. Os 28 pacientes com a neoplasia apresentaram maior frequência de vírus da hepatite C (57,1%) e da hepatite B (28,5%) em relação aos 65 não portadores, que foi de 27,7% e 4,6% respectivamente. O MELD fisiológico e corrigido dos portadores de carcinoma hepatocelular foi de 11,9 e 22,3 pontos, enquanto que o dos pacientes sem foi de 19,4 pontos, maior do que o MELD fisiológico e menor do que o MELD corrigido dos portadores. O tempo em lista de espera dos com a neoplasia foi de 96,2 dias, menor do que a dos sem a ela que foi de 165,6 dias. A sobrevida em três meses e em um ano dos pacientes acometidos pela neoplasia foi de 85,7% e 78,6%, igual à sobrevida dos não acometidos que foi de 77% e 75,4%. Conclusão : Os portadores de carcinoma hepatocelular apresentaram menor MELD fisiológico, menor tempo em lista e maior MELD corrigido em relação aos não portadores. A sobrevida em três meses e em um ano foi igual entre os grupos.
